How to use the cartridge comes in a sterile pack. Double-cleanse (cleanse and repeat) then wipe the skin clean with an alcohol wipe. Fully tie back your hair, away from your face. Work in small areas and apply serum to each area before needling. This will help to ensure that the pen does not drag or pull on the skin. The recommended pattern to move the pen for best results is vertical, horizontal, and then diagonal in both directions. Using a light pressure and without dragging, repeat this motion over each area two times. Please note: comprehensive instructions are included with the device, including diagrams and helpful advice to get the best results.